I would say it would be very difficult. If not for the biohazard node and bane, but vigor and power struggle nodes. Power struggle makes it very difficult for Ghost to get to an L2 which is where she deals most of her damage. You could chain L1s, but they don’t deal nearly as much damage, plus you gain all those precision passives which hinder her ability to phase. Add on the fact CB is really annoying with his debuff conversion and it’s really hard to build up her fury to pack a harder punch too. I wouldn’t say impossible, but it’ll certainly be very challenging.
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I’m not the best ghost player but I’m good. Rank 3 definitely not lol.