You might need a 5/50 or 3/45 before you can explore act 4 as the chip damage from Chaos node and block damages your champions will suffer is going to cost to quite a bit of potions when doing the long paths.
I don’t know actually if you can get level 60 Very close most definitely I’d do as much of act 5 as you can get to test the waters But definitely do the EQ 100% as much as you can 100 act 4 is such a pain and hassle