I think I may have figured out most of the new puzzle

The_Prankster16

1 & 2: These could be almost anyone from the black widow movie/falcon & winter soldier show.
- Red Guardian
- Yelena Belova
- Baron Zemo
- Black Widow/Taskmaster new movie version
- Falcon/Winter Soldier new show version

3: Man-Thing. Confirmed, related to Howard.

4 & 5: Spider-Woman and Lizard. Jessica drew would be an easy link for Spider-Gwen, with Lizard being very pivotal in Gwen's origin (although not the Curt Conners one).

6: Elsa Bloodstone. Confirmed, a monster hunter like Blade.

7: Guillotine 2099. Confirmed, connected to Guillotine.

8: Professor X. Connected with all original X-men and Illuminati.

9: Apocalypse. All four champs around him have been horsemen at some point, and he would be an easy character to pair with Xavier.

10 & 11: Daken & Mystique. Both closely related to Logan, as well as Weapon X

12: Really any of the other New Mutants. My bet's on Cannonball

13: Nova. Was a part of the New Warriors, and is connected to Capt. Marvel (Richard or Sam?)

14 & 15: 2 possible combinations for me
- Cloak & Dagger (More likely)
- Speedball & Penance

16: Any of the Elders. Not really that knowledgeable on them.

17: Harry Osborn. Not sure if a new GG, American Son, or a version of Hobgoblin

18-21: Connected to SS is Mr. Fantastic. Slightly larger square in the middle is Doom. 2 squares on the sides are Valeria and Franklin (Probably NPCs)

22-25: Biggest square is Galactus, who is connected to the "black hole". Smaller squares could be Heralds like Terrax.

26: Probably Blackheart or Damian Hellstrom

I didn't fill in any characters who weren't connected to anything, since they could be anyone.
The "black hole" is probably something very powerful, like the celestials, which is why I think 22 is Galactus.
No idea of what those bottom 2 champs are, especially the one glowing red.
(Also, can we have a "speculation" category for discussions?

Lufaso

Black Hole is the Eternals, a movie is coming

XxLoganTDCxX

Interesting. I think Armour could come in. The mutant.
I would like to see the Lizard but not another spider man/woman
I could see Falcon with a shield
Prof X looks guaranteed
Apocalypse looks good too
Looks like a great year and I hope some/most of your predictions are right!
H.E.R.B.I.E? Wizard?

Rockypantherx

Lufaso said:

Black Hole is the Eternals, a movie is coming

I think the eternals are probably those two near the avengers and Omega Academy. My bets are on black Knight and the leader of the eternals(mind blank, can’t remember her name). I reckon yeh black hole is probably Entropy, we’ve already seen them

The_Prankster16

26 (the one next to Mephisto) could also be Ereshkigal, the goddess who made Guillotine's sword from the new motion comic.