How to deal with safeguard+immunity?

SkyeBerry

This seems a bit stupid to be honest. Here's a node where you can only do reasonable damage with debuffs of some sort, and now here's a node where screw you you can't do that. Go ahead and hit this enemy 100+ times, by the way they KO you in one hit, and your evade only registers like 50% of the time

Jefechuta

Can you show the nodes pls?

magnus_xix

Ability accuracy reduction

willrun4adonut

Falcon

phillgreen

Crossbones

AmaadAkira

Passive debuffs also work ie human torch, nimrod (sp2 at 10 charges), kitty sp1 while phased etc.