I'd say at least Omega, Colossus, and ProfX are R3-worthy. YMMV on the rest.
If this is a very early R3, I'd consider holding onto it and see if you're options improve, or you awaken some of them (OR in particular gets much better awakened). If this is a TB rank up, I'd pick between OR and Colossus and just bite the bullet.
Colossus is a bit of a tank, benefits from the dupe but it's not essential. Storm was a good buff and she can put out some pretty hefty damage. Toad has some uses but I'm not an expert so can't really comment.
It's a bit hard without knowing where you are in the game, Cavalier moving up to Thronebreaker or something else.
Weirdly, I might be tempted to wait a bit until you give yourself some other options. My Bishop R3 is an absolute monster, Kitty Pryde is worth the praise she gets and Red Mags has some very specific uses.
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If this is a very early R3, I'd consider holding onto it and see if you're options improve, or you awaken some of them (OR in particular gets much better awakened). If this is a TB rank up, I'd pick between OR and Colossus and just bite the bullet.
It's a bit hard without knowing where you are in the game, Cavalier moving up to Thronebreaker or something else.
Weirdly, I might be tempted to wait a bit until you give yourself some other options. My Bishop R3 is an absolute monster, Kitty Pryde is worth the praise she gets and Red Mags has some very specific uses.