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Which 5 star heroes (unduped) should I upg for Act 5?



I recently started working on act 5. Need suggestion on which of these 5 star heroes would help well.
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Hyperion and Venom are also both amazing champs - Venom is a bit more situational than Hype (anti-spidey-squad)
Symbiote Supreme is a solid mystic, provided you're facing someone with buffs
Gamora is great after her buff, solid damage and can ignore MISS mechanics if you can keep her buff count >10
Looking at your 4* (keep in mind that they're effectively useless once you move into Act 6)
Hercules, Nick Fury, Archangel, and Quake - an amazing set who can still help you throughout Act 5.
Scarlet Witch can still do great stuff if you can get her awakened and sig level max