What aspect of the game should I focus on to make progress

I’ve just completed act 5 for the first time and am stuck on 6.1.1 while it may just be a skill issue I wanted to ask for tips.
Act 1,2,3 have been explored as well as 4.1
Act 1,2,3 have been explored as well as 4.1
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Annddd Back to story.
story is the only way.