Guardian lane has Valkyrie who's an absolute menace with those nodes. The only fight i truely struggled against when i did my first run with Kate in 22 revives. Heard Vision is the "best" option, but the downside is you have to use arguably the worst tech champ in the game when it comes to damage. And mine is only r1 (i wouldnt r2 him if you paid me)
Apoc path has Herc which ive seen people struggle against. Then again i saw
@willrun4adonut mention he soloed with Guilly just not throwing specials . (Mine is only r1)
Trap nodes seem pretty chill for both