I'm guessing your Domino is 5/65, she's a great option, but I'd suggest bringing in Red Hulk in place of Deadpool and switch off the Suicide masteries.
I think the Heavy incinerate damage with the full flaming trinity will more than enough make up for the lack of Suicide Masteries.
I fully explored LOL with unduped Domino 5/65. In my team i always had Masacre and Rhulk, the other two slots were for utility/synergies based on the path i was doing. I didn't run suicides because the l1 spam when the opponent has a heavy critical bleed. Anyway i recommend to always bring another useful champion such as Sparky (as i did for most of paths), in that case bringing Miles Morales would be a great option.
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I think the Heavy incinerate damage with the full flaming trinity will more than enough make up for the lack of Suicide Masteries.
In my team i always had Masacre and Rhulk, the other two slots were for utility/synergies based on the path i was doing.
I didn't run suicides because the l1 spam when the opponent has a heavy critical bleed.
Anyway i recommend to always bring another useful champion such as Sparky (as i did for most of paths), in that case bringing Miles Morales would be a great option.