Champion Spotlight - Anti-Venom

edited October 2021 in Champion Spotlights

About Anti-Venom
Eddie Brock, now separated from the Venom Symbiote, had his cancer cured by Martin Li, the alter ego of the Supervillain Mister Negative. Unbeknownst to Li, his healing powers fused with the remnants of the Symbiote in Eddie’s body and created a new mindless Symbiote now known as Anti-Venom.

Anti-Venom's Mechanics

    Anti-Venom inflicts a selection of three Debuffs on the Opponent when reaching a Combo threshold. Once the Opponent has been Debuffed he can choose to consume the Debuffs and turn them into stacks of Fury with his Special 2, which increases his damage output substantially. It is possible to increase the amount of Debuffs Anti-Venom can inflict on the Opponent, which consequently increases the amount of stacks of Fury Anti-Venom can acquire.

   Health  Attack  PI (Max Signature)
 3-Star  6366  445  1928
 4-Star  15812  1103  4794
 5-Star  31703  2211  10630
 6-Star (Rank 3, Level 45)  40851  2849  13660

Character Class: Science

Basic Abilities: Spectre, Disoriented, Decelerate, Fury

  • Mystic Unblockable Counter
  • Anti-Venom is able to reduce the Ability Accuracy of Unblockable from Mystic Champions up to 100%.

  • Heal Inverse
  • The Spectre and Petrify Debuffs, together with his Signature Ability and the Despair Mastery, can reduce Heal effects to the point of inversion.

  • Utility
  • Anti-Venom has an unlimited duration of Slow and Disoriented Debuffs.
  • Cleanse and Purify
  • Champions that can cleanse or purify when attacking won’t have much to worry about.

  • Combo Control
  • Champions that are able to control their Combo Meter may be able to avoid Anti-Venom Debuffs from triggering most of the time.

The following Stats and Abilities are based on a Rank 5, Level 65, 5-Star Champion

Always Active
  • Immunity to Incinerate and Poison.
  • During the Opponent’s Special Attacks Anti-Venom gains 40% Defensive Combat Rate per Debuff on the Opponent.
Developer’s Note: Anti-Venom can gain quite a bit of Power when blocking or receiving attacks, and thanks to his Signature Ability, he can do so while not losing too much health.

Genetic Memory
  • When the fight starts Anti-Venom inflicts an indefinite Klyntar Debuff. If this Debuff is removed by any means it comes back after 15 second(s).
  • If the Opponent is suffering from the Klyntar Debuff, for every 10 hits in the Combo Meter from either Champion, Anti-Venom inflicts the selected Genetic Memory Debuff from the list below. Max Genetic Memory Debuffs 4.
  • Spectre Debuff: Reduces the Opponent’s Regeneration Rate by 16.66%
  • Disorient: Reduces Defensive Ability Accuracy and Block Proficiency by 12.5%.
  • Decelerate: Lowers Evade and Unstoppable Ability Accuracy by 33%.
  • Second Medium Attack changes the selected Genetic Memory Debuff to the next Debuff in the list. Defenders have a 50% chance to change the selection when inflicting a Genetic Memory Debuff.
Developer’s Note: A key aspect of playing with Anti-Venom is knowing which Debuffs to stack first against certain Champions.

Klyntar Debuff:
  • Klyntar Debuff reduces Physical Vulnerability by 525 and gains additional properties based on Anti-Venom’s Opponent.
  • #Spider-Verse Heroes: Reduce the Ability Accuracy of Evade effects by 100%.
  • Mystic Champions: Reduce the Ability Accuracy of Unblockable by 65%. At 30 hits in the Combo Meter from either Champion it increases to 100%.
Developer’s Note: This Debuff coupled with Decelerate is able to completely counter Mystic Champions that make use of Unblockable and Unstoppable.

Heavy Attacks
  • Inflict a Stagger that lasts for 10 second(s). A Staggered Opponent has their next Buff Nullified. Max 2 Stacks.
Special Attacks
  • Personal Passives are paused during Specials.

Special 1 - Constituent Hammer
  • If not already active, gain an Accelerated Mutation Passive, causing Anti-Venom to inflict an additional Genetic Memory Debuff for 15 second(s). Triggering Accelerated Mutation also refreshes the Evolved Mutation Passive.
  • If Accelerated Mutation is active, all hits deal a burst of 884.4 Physical damage.
  • First hit inflicts a Petrify Debuff, reducing the potency of their Power Gain and Regeneration effects by 40% for 20 second(s).
Developer’s Note: A very important aspect of his kit is being able to use Special 1 to refresh Evolved Mutation Passive from Special 3. If you can keep this Passive refreshed, Anti-Venom damage increases by a lot.

Special 2 - Constituent Spear
  • On activation consume all Genetic Memory Debuffs on the Opponent, granting a Fury Passive per Genetic Memory consumed, gaining 1658.25 Attack Rating for 25 second(s).
Developer’s Note: Timing the use of Special 2 can make a huge difference when it comes to his loop. You need to be able to time the activation in such a way that would allow Anti-Venom to loop back to Special 1 so he can refresh the Evolved Mutation Passive.

Special 3 - Purge
  • Inflict a Rupture Debuff, dealing 1547.7 Physical Damage over 15 second(s).
  • Gain a non-stacking Evolved Mutation Passive, increasing the max number of Genetic Memory Debuffs by 4 and increasing Fury potency and duration by 25% for 25 second(s). The max stack for an individual Debuff is 4.
Developer’s Note: In longer fights Special 3 plays a key role in his loop. It allows Anti-Venom to inflict more Debuffs and consequently gain more stacks of Fury.

Signature Ability - Controlled Symbiosis
  • When Attacked:
  • Anti-Venom gains a Passive Regeneration stack that recovers 65% of the Attack Damage taken from a non-Critical Hit over 20 seconds and is interrupted if the Klyntar Debuff is Purified.
  • Personal Debuff potency is increased by 10% for every 10 hits in the Combo Meter from either Champion. Non-personal Debuffs are increased by 5% for every 10 hits in the Combo Meter. Effect caps at 50 hits.
Developer’s Note: At 50 hits in the Combo Meter and with the Accelerated Mutation Passive active, Anti-Venom only needs one application of each Debuff to get most of its utility, since Accelerated Mutation inflicts 2 Debuffs each with 50% increased potency, which is the equivalent of 3 Debuffs at normal potency.

Close Family: - with Venom, Cargnage
  • Anti-Venom: #Symbiote Opponents have the Ability Accuracy of their Buffs reduced by 50%.
  • Venom, Carnage:Regenerates 15% of max Health when knocking out #Spider-Verse Heroes.
  • Unique Synergy: Does not stack with duplicate synergies.

TIME TRAVELERS - with Spider-Man 2099,Doctor Octopus
  • Anti-Venom: For the first 10 second(s) of the fight the Opponent cannot gain Buffs.
  • Spider-Man 2099: On the start of the fight, inflict a Wither Debuff on the Opponent, reducing Ability Power Rate by 125% for 15 second(s).
  • Doctor Octopus: When dealing damage per Breakthrough removed on a Heavy Attack, 25% chance per Breakthrough to inflict another burst of damage dealing Attack Rating in damage.
  • Unique Synergy: Does not stack with duplicate synergies.

MAYBE LATER - with Agent Venom
  • Anti-Venom: Inflicting a Genetic Memory Debuff deals a burst of 40% of Modified Attack in Physical Damage.
  • Agent Venom: Gain 10% Power anytime a Debuff is purified.
  • Unique Synergy: Does not stack with duplicate synergies.

COUNTER MEASURES - with Green Goblin
Anti-Venom: Klyntar and Genetic Memory Debuffs are not affected by Ability Accuracy reduction.
Green Goblin: Afterburner inflicts additional stacks of Incinerate Debuff equal to the amount of stacks of Madness.
Unique Synergy: Does not stack with duplicate synergies.

Headache - with Punisher
Anti-Venom: Against #Villains Fury effects gain 30% potency.
Punisher: Gain 30% Offensive Ability Accuracy against #Villains.
Unique Synergy: Does not stack with duplicate synergies.

  • Together with Spectre and Petrify, Anti-Venom can easily reverse the Opponent’s healing.

Inequity Precision & Cruelty
  • Anti-Venom puts tons of Debuffs on the Opponent, making the most of this Mastery.
Post edited by Kabam Zibiit on


  • What can I do to get the anti venom character because I didn't get it
  • Danemo666Danemo666 Posts: 113 ★★

    What can I do to get the anti venom character because I didn't get it

    Did you complete at least one set of September objectives?
  • TrackerX55TrackerX55 Posts: 41
    Is he a Science or Cosmic

  • Kript_king2Kript_king2 Posts: 3
    I feel sorta disappointed with his abilities as in the comics he is known as the wretched healer with the ability to heal almost anything and his touch is deathly dangerous to symbiotes, yet he doesn't do anything to symbiotes and his regen factor isn't that good not to mention his debuff based skill set is very difficult to control. And maybe make it so that during accelerated evolution he deals physical damage with all of his attacks instead of only his sp1. He was so over hyped and I feel he left a disappointed feeling though his animations and the idea behind him is AMAZING but he needs a better regen factor, easier control over his debuff placement, during accelerated evolution all attacks for the remainder of the buff deals physical damage, and a extra edge over symbiote characters. But thank you for bringing him to the game and for working so hard its so cool and I really hope you listen to my suggestions.
  • Crine60Crine60 Posts: 1,017 ★★★★
    @Kabam Zibiit I have multiple questions about this spotlight.

    The first thing is just a comment that doesn't really matter, but I find it confusing that your description says he is mindless and then the first time we see him in EQ he is talking. I would never think a creature described as mindless would have the ability to speak, let alone in a coherent manner.

    Okay, questions:

    Is there overlap between disorient and decelerate's effects? Disorient has DAAR and decelerate can reduce evade but doesn't DAAR decrease at least some champs' evade (falcon using lock on for example) also?

    Klyntar debuff says it reduces physical vulnerability. Is that on Anti-Venom or on the opponent? If it applies to the opponent (which I thought having a debuff on an opponent applies the negative effect to the opponent) isn't that actually beneficial to them? Did you make a typo or do you have a different understanding of the word vulnerability than I do? Vulnerability is weakness, so reducing a weakness is beneficial. If you reduce the opponent's physical weakness aren't you actually giving them physical resistance?

    The klyntar debuff developer's note says that it, coupled with decelerate, allows you to completely counter Mystic champs who use unblockable and unstoppable. The unblockable AAR seems unique to a Mystic enemy and is tied only to the klyntar debuff however the ability to decrease unstoppable ability accuracy seems to be only from decelerate, which other than needing the klyntar debuff to generate a genetic memory debuff, doesn't seem to come from the klyntar debuff directly itself. Since decelerate says nothing about Mystic champs it seems like it should affect the unstoppable of all classes of champs which makes the developer's note a little misleading or poorly worded from my view.

    The sig ability differentiates between personal and non-personal debuffs, can anyone provide clarification and examples of the differences between these two terms?
  • Crine60Crine60 Posts: 1,017 ★★★★
    Okay, I understand that mindless comment in regards to the symbiote meaning it isn't maybe sentient on its own but that combined with Eddie, as Anti-Venom the Eddie part is still sentient and so he can talk, etc. Nevermind that part.

    I also see the in-game description says the klyntar debuff reduces physical resistance not vulnerability as the spotlight says so that appears to be a typo on here.
  • Why can't I get anti-venom by the summoned symbiote
  • BigPoppaCBONEBigPoppaCBONE Posts: 1,697 ★★★★
    Decelerate isn't working on Abyss Thing. 4 stacks and he's still going Unstoppable. Works just fine everywhere else and against other Things.
  • DiablordDiablord Posts: 500 ★★

    Decelerate isn't working on Abyss Thing. 4 stacks and he's still going Unstoppable. Works just fine everywhere else and against other Things.

    Abbys thing has increased ability accuracy, Decelerate only decreases chance but does nto prevent unstoppable's effects.

  • BigPoppaCBONEBigPoppaCBONE Posts: 1,697 ★★★★
    Since when was it increased at the start of the fight? It works as expected against other unstoppable champs, including other Things in other content. 132% AAR should keep it from proc'ing at all.
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