VOID! Medusa isn't doing as well anymore being a defender in AW. She's great and all but Voids utility is so unique, also watch a few videos on how to give that MASS damage. He's just amazing.
Void's damage over time is sick! I don't think you can go wrong with either. Rank up who you need more based in their abilities. If you're more comfortable fighting with one, prioritize it.
Medussa has greater damage and works best if you have blackbolt, karnak and ronan/kamala khan. She is an option for LOL and is great against robots (e.g. final ultron boss) and a solid aw defender. Her auto block can also save you if you scrub up now and then. Downside is her furies trigger mystic dispersion in aw offence. Her poison immunity is useful.
Voids damage is much lower and he really needs a high sig level to be most effective. He starts slowly but hits much harder with fear of the void. His ability to deal with powergain and regen means he can handle nearly any fight and doesnt have any really bad matchups save for nodes that autobleed or poison. He also has higher pi than medussa at high sig levels so if you are pushing for prestige he will help a little.
I have both 5*s at r4 and personally would choose medussa unless you already had a couple of damage dealers like hyperion or stark spidey at r4.
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But 5.4.6 Ultron is easiest with Loki lol.
Voids damage is much lower and he really needs a high sig level to be most effective. He starts slowly but hits much harder with fear of the void. His ability to deal with powergain and regen means he can handle nearly any fight and doesnt have any really bad matchups save for nodes that autobleed or poison. He also has higher pi than medussa at high sig levels so if you are pushing for prestige he will help a little.
I have both 5*s at r4 and personally would choose medussa unless you already had a couple of damage dealers like hyperion or stark spidey at r4.