Gods vs Synergy

MCCXVI

For end-game content, such as Act 5 Chapter 2, is it better to have Gods for questing or Synergy with increased PI?

Team 1 (Synergy): 5* Black Panther 3/45, 5* Storm 3/45, 5* Guillotine 3/45, 4* Magik 5/50, and 4* Magneto 5/50.

Team 2 (Gods): 4* Gwenpool 5/50, 4* Magik 5/50, 4* Captain America WWII 5/50, 4* Vision 5/50, and 4* Wolverine 5/50.

Drizzits

Don't worry about pi. Synergy helps, but not because it inflates pi.
To answer your full question, sometimes even the gods aren't the right tool for the job. Champs that accomplish the specific goal have more value.
Is it a high sustain map (most end game content)?
Do you need poison/bleed immune?
Etc, etc. If there's synergy, great. If not, most times it won't break you.

Unknown

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Blackbeard

Well as far i have seen, for any quest you need some basic ability heroes. Champs who bleeds, champs who regens, champs who power lock or burns. Bleed and poison immunity is a good addition with this. If you have the champs pls check the synergy as you are asking about synergy team, venom, agentvenom, electro, spidy classic, spidy symbiot. A hell lot of health, attack, perfectblock, crit rate and crit damage bonus. But this team eventually fails because low health and armor rating.
But as the ability team i preffer,
1. Ultron (immunity, regen, bleed, stun),
2. Magic/Guilly/voodoo (power lock, health recover in limbo/bleed, rev regen, regen if awaken/regen, power burn, poison),
3. Hulk (super fury, killer sa),
4. Ronan/Hyperion/venom (poison immune, rev buff, stun/power gain, stun, incinerate/bleed, buff stack),
5. Blackpanther/ Wintersoldier/ electra/ gwenpool (bleed/ammo pileup, power burn if awaken/bleed, assassin/ bleed),
6. Wolverine/x23/Rogue (bleed, regen/bleed, regen/ health steal, power steal).
All of them still got 2 common ability, high health and attack except mutant ones. This team will work fine in any level.