Bane

In Act 5.2.5 when the Bane Debuff is applied to my champs it reduces 2.5% Of my champions max health over 10 seconds which is what it supposed to do to the defender as well however it only reduces 2.5% of the defenders health in 10 seconds. So example. If my champs have Bane on them at max health they lose 25% of their health over 10 seconds which leaves me with 75% but when applied to the defender they only lose 2.5% of their max health over 10 seconds which leaves them at 97.5%.
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The degen is based on the other champs health. So when the defender has Bane, they are draining at 2.5% of YOUR health. If YOU have Bane on you, then you're draining at 2.5% of the opponent's health.
If the defender has a much larger health pool (like in Act 5), the degen can be nasty against you and minimal against them. This is part of why facing the Collector is so difficult. One hit and the Bane kills you in seconds.