4* Champions Worth Ranking Up Once you are focused on 5*

Once you're focused on 5* champions, are there any 4* champs that are still worth taking up to 5/50?
Any that are worth taking up ONLY if you don't have them as a 5*
Any that are worth taking up even if you have a 5*?
How many 5/50 would you want to have to help with arena grinds?
I'm firmly focused on 5* champs now (I've got almost 50, plus several that would be considered "god tier") but often wonder whether some of my 4* are still worth investing materials into.
Any that are worth taking up ONLY if you don't have them as a 5*
Any that are worth taking up even if you have a 5*?
How many 5/50 would you want to have to help with arena grinds?
I'm firmly focused on 5* champs now (I've got almost 50, plus several that would be considered "god tier") but often wonder whether some of my 4* are still worth investing materials into.
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Comments
But there are still some 4-star champs that can wreck lots of content.
(I still think Kabam should extend the restriction to include 5/50s, because you'd have to invest a fair bit of stuff in order to bring 4-stars in... it would still classify as part of a 'mature roster'...)