I took a path in 6.3.5, which had the node combination "Cramping" and "Long Distance Relationship". I used CapIw against the this node combination by adding a skill champion onto my team , knowing that I will be purifying the weakness debuff coming from "Long Distance Relationship" node. However, even when the skill champion synergy from CapIw's signature ability triggers and purifies the debuff, the passive power drain from the Cramping node is still active and keeps draining my power. This interaction is clearly bugged, I will be uploading video proof as well.
https://www.youtube.com/watch?v=hyAVAPh8Nv8Around the 1:15-1:20 mark . in the video I have no weakness applied to me and I still have the passive power drain applied to CapIw. The node clearly states, "while under the effects of a weakness debuff" so this interaction is bugged.