Who to take to rank 5 as a 5*

In a world where every champion procs buffs every couple seconds and starts auto-blocking when they have less than 15% health, Venom would be better than those two.

In general, I think Blade is the better choice. As @Raganator says, he saves potions and units, and can do so into Act 6. I think he's starting to get significantly undervalued these days, especially by people who think his only worth is Danger Sense.

Honestly I have all three at rank 5 (Blade, Sparky, Venom) and I find them all situationally very useful. I think they are all worth it, and it depends on what the individual player needs most at the moment. But I ranked Blade to r5 very early on, and never regretted that decision.

Graydrox

DPX. When you are getting your ass kicked, which is to be expected when using him, you get sweet power gain. Lose win.

Hector_1475

neither

Quite the opposite.

Both.

TheHeroDeserved

Did it with a r5 tech gem. Probably wont have done it without. Quite glad with the result however, even though he's a bit of a glass canon. With a couple of others r5 (Cap, Domino, Ghost, Hyperion and Namor), I'll probably wont use him for act 6.