Fury, Medusa and Omega are amazing champs, but really need to be duped. For near term progress I would consider She-Hulk and Iceman. Ultimately make sure you rank up champs you feel comfortable playing!
Fury and Omega yes, Medusa not so much
Medusa, Omega IMIW, Spider-Gwen and Nevula are great champs for you to rank up now. I wouldn't rank up Fury any more until he's duped. If you're finding it too difficult, back off of story for a bit and do some event quests and stuff. Get those champs at a higher rank, it'll be way easier. And don't rank up 3 stars any more. It'll just be a waste of your resources. If you dupe Omega, he's best with a high sig. Medusa and Nick are great as soon as they're duped.
Medusa, Omega IMIW, Spider-Gwen and Nevula are great champs for you to rank up now. I wouldn't rank up Fury any more until he's duped. If you're finding it too difficult, back off of story for a bit and do some event quests and stuff. Get those champs at a higher rank, it'll be way easier. And don't rank up 3 stars any more. It'll just be a waste of your resources. If you dupe Omega, he's best with a high sig. Medusa and Nick are great as soon as they're duped. Ok thank you! I'm onto 4.4.1 and am definitely going to hold off for a while, I just used a mutant gem to awaken Omega and will put some stones in him and focus on ranking him up, I can use a basic gem on Nick, is he worth it?
Medusa, Omega IMIW, Spider-Gwen and Nevula are great champs for you to rank up now. I wouldn't rank up Fury any more until he's duped. If you're finding it too difficult, back off of story for a bit and do some event quests and stuff. Get those champs at a higher rank, it'll be way easier. And don't rank up 3 stars any more. It'll just be a waste of your resources. If you dupe Omega, he's best with a high sig. Medusa and Nick are great as soon as they're duped. Ok thank you! I'm onto 4.4.1 and am definitely going to hold off for a while, I just used a mutant gem to awaken Omega and will put some stones in him and focus on ranking him up, I can use a basic gem on Nick, is he worth it? Definitely worth it. The question is whether or not to put it in Nick Fury or Ægon. But for someone at your level, you don't need Ægon, plus you'd need to split sig stones between him and Omega. I'd definitely put any sig stones you have into Omega, awaken Nick and don't put any sigs into him. Rank them both up as high as stinkin' possible. Make sure to look up videos on how to use your best champs. Nick and Omega will make Act 4 so easy, you'll love it. In fact, the second you awaken Nick Fury, it should become so much easier.