If you awaken that Medusa, you do.
What's the easiest path leading up to him?
You can use Nick fury plus units. If you are powering through on your first run, then he should work. You're going to get poisoned rather quickly. But if you have the units and really want to get it done and don't know how to use quake nf will do it. Also, if you can get to 10+ tactical charges you can just heavy attack sinister to death and remove all debuffs. This will get rid of the poison but not the shocks. If you are only using heavies in the end you shouldn't be dexing anyway.
You can use Nick fury plus units. If you are powering through on your first run, then he should work. You're going to get poisoned rather quickly. But if you have the units and really want to get it done and don't know how to use quake nf will do it. Also, if you can get to 10+ tactical charges you can just heavy attack sinister to death and remove all debuffs. This will get rid of the poison but not the shocks. If you are only using heavies in the end you shouldn't be dexing anyway. Don’t you need angela heimdal synergy for quake?