I looked at my roster and decided to do Variant 5 with whatever champs I had.
Chapter 1:
Used whatever Symbiote or Spiderverse champions I had.

For quest 2, I swiped Starky with a 3 star Mephisto and took the Iceman path.
Chapter 2:
Dr Voodo mvp. Used Jane Foster for chain stun and it kinda worked.

I had no viable poison immune champion for Scarlet Witch so, I begged her not to activate poison :P
Chapter 3:
Venom and Symbiote Supreme mvp.

Doctor Voodo melted the chunky boy Venom in the final quest.
And here is the result:

Haven’t opened the rewards yet so, I’m hoping for the good stuffs. All in all, it was a mixed experience for me. I’m not a fan of limiting specific champions for a event and having to bring niche counters for some road blocks.Big numbered attack values didn’t help either.But I think anyone with good enough skill, required champions and a little pinch of units can do this Variant