Who should be my first 5* Rank 4

AlbinoDarkElf

Gonna finish up exploring uncollected event quest, then headed back to push act 5.3.1
Only have 12x 5*'s right now, and no real good synergy options even of 4* or lower like (Nick Fury, Apocalypse, etc)
So just running my 5 "strongest" characters. So without synergies who should I rank up?
(5*'s not on the poll, Cable, Nova, Agent Venom, Spider-Man (classic), and Daredevil (classic).)

AlbinoDarkElf

If you could explain why you picked who you did that would help me a lot. I'm a bit new and don't know the minutiae of the characters.

Etjama

Guillotine 2099

If you can keep a combo, G99 is a great first R4. She can really hit above her weight and has a lot of good utility to offer.

tofuシ

Captain Marvel (Movie)

I misclicked but g2099 as a first rank 4 is awesome she is a good counter to crossbones in 6.1.5.

Sormor

Domino

Domino is great out of the box. Guilly2099 is great too, but she requires you to be able to keep a long combo. If you've got the skills, g2099 is probably the better option, but I voted Domino since she's just solid.

AlbinoDarkElf

Tied up now between CMM and Guilly2099 AHHHHH. Anyone else have any opinions?

joedirt6969

Havok

I like havoc. He does serious damage