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Best rank-ups for 6.2.2 and beyond

Final_OrderFinal_Order Member Posts: 128
As title. I've got a decent amount of high tier champs already but none want to break the barrier that is the impossible Mr Sinister. Also, tips for the rest of act 6 would be greatly appreciated! I already have:
6* R2 Kitty Pryde, Shang-Chi and Gladiator Hulk.
6* R1 IMIW, Heimdall, Air Walker, Spider Gwen, Mangog
5* R5 Domino, Red Mags, Sunspot, CGR, Aegon
5* R4 Void, Diablo
5* R3 Mephisto, Dragon Man, The Champion
5* R2 Colossus, Cap IW

These are most notable. Any tips would be really helpful! (If you mention other champs that I think I have, I'll reply)
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