What's your worst match-up?

I've had a lot of bad ideas throughout the years - taking my Punisher 2099 against Thing; taking my Red Magneto against Omega Red and trying to out-bleed him (that somehow worked, but I don't recommend it) - but I think I've got another fight that takes the cake. I present you with Gwenpool vs. Colossus in Variant 8.

So, a lot of things are happening here that are really bad. The first, obviously, is that Colossus is bleed immune and all of Gwenpool's abilities (or at least their upkeep) hinge on her ability to bleed her opponent. More than that, though, it's bad because Colossus has a chance to gain an armor up buff whenever he is immune to an effect. As you can see, he was gaining a bunch of armor ups and my measly sword swings did hardly any damage at all.
In addition to that, Gwenpool lowers her opponent's ability accuracy whenever she hits them. However, Colossus has an ability where he gains double combat power rate when his ability accuracy is modified. This was news to me, so I was left confused as to why he constantly soared to his SP2. A special attack that has a chance to double every armor up buff on him. The result is that it was very, very easy to push him to 100+ armor ups, as you can see in the image. It did not take those full 94 hits to do so - I just wanted to get a screenshot, and that took a bit of time since the screen recorder was bugging out on me a bit.
Right after that screenshot was taken, I gave up. I went in with Venompool instead. It was an annoying fight since he was immune to all of the damage types I had available, but Venompool's range of buffs eventually just out-damaged Colossus' armor ups.
What unfortunate situations have you found yourself in?

So, a lot of things are happening here that are really bad. The first, obviously, is that Colossus is bleed immune and all of Gwenpool's abilities (or at least their upkeep) hinge on her ability to bleed her opponent. More than that, though, it's bad because Colossus has a chance to gain an armor up buff whenever he is immune to an effect. As you can see, he was gaining a bunch of armor ups and my measly sword swings did hardly any damage at all.
In addition to that, Gwenpool lowers her opponent's ability accuracy whenever she hits them. However, Colossus has an ability where he gains double combat power rate when his ability accuracy is modified. This was news to me, so I was left confused as to why he constantly soared to his SP2. A special attack that has a chance to double every armor up buff on him. The result is that it was very, very easy to push him to 100+ armor ups, as you can see in the image. It did not take those full 94 hits to do so - I just wanted to get a screenshot, and that took a bit of time since the screen recorder was bugging out on me a bit.
Right after that screenshot was taken, I gave up. I went in with Venompool instead. It was an annoying fight since he was immune to all of the damage types I had available, but Venompool's range of buffs eventually just out-damaged Colossus' armor ups.
What unfortunate situations have you found yourself in?
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Comments
I literally just had the most annoying match so far in Act 6 . This guy literally has no straight counter except Void . Torch might work but need a r3 Torch ...i ended up buying a team revive in the end.
Massive buffet and aspect of war makes this Ultron super super super annoying . Anybody who has done this will relate .