It really depends on where you are in the game right now plus the champions you currently have ranked and are planning to rank.
You can check out different mastery setups on Youtube but most of them cater to really endgame stuff so until you tell us where you are right now in the game and your roster, we can't really recommend which one will fit your roster.
There are two general setups:
Full suicides (3/3 on both Double Edge and Liquid Courage plus Willpower at 3/3) Assassin's (with or without Mystic Dispersion)
Each of those cater to a different playstyle and goal.
Comments
You can check out different mastery setups on Youtube but most of them cater to really endgame stuff so until you tell us where you are right now in the game and your roster, we can't really recommend which one will fit your roster.
There are two general setups:
Full suicides (3/3 on both Double Edge and Liquid Courage plus Willpower at 3/3)
Assassin's (with or without Mystic Dispersion)
Each of those cater to a different playstyle and goal.
Put just one point and open up as far to the right side of the 'tree'.
Roughly like this.