Which mutant and skill champions should I rank 3?

I have no high-ranking mutant or skill 6* champions and I really want to have a chamion for every class at least r3 so I was wondering which 1 skill and which 1 mutant champion I should take up.
*Note* If it help I will be going into act 7 soon



*Note* If it help I will be going into act 7 soon



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Mutant: Colossus (he needs high sig though imo)