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7* Cosmic Awakening Gem

Just pulled a 7* Cosmic AG from an AG crystal, and I'm currently undecided on who to use it on. I know that both Medusa and Hyperion are sig one-and-done type champs who benefit massively from the awakening, but I want some feedback on whether champs like Knull, SIM, or BRB will get a big benefit as well. Would also like to know if any of these guys are r3 or r4 worthy if they are to be awakened, and how much sig investment is needed. I would prefer a near-zero sig investment as I'm quite low on sig stones and need to give them to my 7* Guardian. Anyways, here's my roster:


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Medusa has true accuracy, fervor, armour break, shatter, stun, bleed and autoblock at 3 furies.
Hyperion also has very good damage, power gain, regeneration and stun-armour break chance on SP2.
Very solid, also.