I just wanted to share something that I think is a fairly cool piece of Spidey Supreme's utility: he's a great counter to Domino. Since he's practically immune to ability accuracy reduction, Domino is unable to make almost all of his abilities fail, which neutralizes most of her threats. The only abilities that I think she can fail are Spidey's stuns and dexes, but those two things are largely irrelevant anyway if you play Spidey right.
The entire rest of his kit is unaffected by ability accuracy reduction, meaning he works completely uninterrupted by Domino's usual shenanigans.
While this is an r4 Spidey Supreme versus an r3 Domino, he KOs her with the first hit of his SP2 (that is, before any of the three subsequent hits with their big bursts of energy damage), so I'm fairly confident that he could have defeated an r4 Domino in roughly the same time. The rest of that SP2 could probably have knocked off an additional 20% health without any issue.
https://www.youtube.com/watch?v=NX-xOW1DHR4A few other things of note: this is how well he can work against champions without any buffs whatsoever. Additionally, that is all his own power gain. He doesn't inherently deal DOT so Polka Dot Power doesn't help him and he's not a Saga champ so he doesn't benefit from the Saga node that both deals DOT and plays into Polka Dot Power. But once he gets cooking, his power gain gets cooking and he doesn't need no stinky nodes to help him out.