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It's worth doing the monthly EQ everytime if you have the champs
Looks like my post didnt go through.
By pixie side quest, i think you mean the gwenpool side quest? It is totally worth it. One of the best in several months. The quest takes hardly any time, gives you the champs to use in the fight and heals your champions after each fight (win or lose). You need to use specific items in their kit to complete objectives and seeingas other than Medusa and Kushala, the others are not meta champs, its a good chance to try others.
Rewards are decent for effort taken