First, let's talk about bugs:
Don't buy large energy refills; I lost a lot of energy for no reason. When you have 1 energy, this bug doesn't happen. So stick with 1 energy.
When you change the proficiency tree, even after everything is saved and working, when you select the page in the tower, it simply doesn't work. You need to restart the game. I lost almost 100 units before realizing I was out of 3/3 recoil (I was using Gentle, so I didn't notice).
Boosts don't seem to work; if they do, the effect is insignificant.
Rewards decreased from room 88 to 92; I don't know why this happened, if it's intentional or a bug, but it was strange.
Tips:
Skill is the easiest to rush. Mutant is the hardest; mutant champions are very RNG. Since the fight only lasts a minute, if you're unlucky with critical hits, you'll time out. Try to prioritize champions that don't rely on critical hits, like Deadpool-X.
The best skill options are Hit-Monkey, BPCW, SF Starlord, Bullseye, Mantis, Okoye, and Patriot also works very well.
If you get stuck in a fight and have already used your strongest champion, you can recover them, put in a weaker champion that can handle that fight, and use your strongest champion in the more difficult fight. You won't need this if you pay attention.
Prioritize your strongest champions against these defenders:
Loki: time doesn't pause during specials, he simply takes all your time casting SP1.
Spider-Man 2099: has a lot of resistance, on higher floors where time is sometimes insufficient, this can be a problem.
She-Hulk: against mutant champions, she simply disables all the abilities of your special attack. If there's a big difference in CR, it will take dozens of attempts until you get lucky.
Some champions have high armor or resistance, which is a problem for mutants in general. You can time out by using Jean Grey against Jane Foster. On higher floors, I recommend stopping and checking the champion's resistances before proceeding.
Considerations:
Some defenders shouldn't be there; some interactions are unfair, like She-Hulk against mutant champions.
Time should pause during defenders' special moves. This makes a big difference on higher floors.
The rewards aren't worth it. Floor 92 is offering me 10% T7B and requires 8 ascended Rank 4 or Rank 5 champions.