No, Safeguard is the node preventing opponent from losing more than xx% health from a single source.
I was stuck on Safeguard Nodes for so Long then I figured out which champs to use and it was a Breeze, if you have Gladiator Hulk, he is by far the best champ to have, Safeguard counts as passive damage and makes Gladiator Hulk go into "face me" mode, making him alot stronger on top of regaining most of any health taken, the team I used to clear all the Safeguard Nodes were Omega Red, Gladiator Hulk, Domino, Quake and Gwenpool
No, Safeguard is the node preventing opponent from losing more than xx% health from a single source. Also in RTTL 3 are multiple that are debuff immune. No bleeds, no parry, especially without shutting down their ability accuracy.