Thing you may not know about Mysterio
I dunno how common this knowledge is but I thought it's worth sharing
When you play as Mysterio against a safeguard opponent, the reflected damage when reflection gas expires isn't subject to the safeguard 1% limit, meaning that you can easily bypass this node, simply by using SP1s and letting the enemy beat you a bit.
In most cases tho, make sure to use his poison debuff on heavy. But against immunity champs this works great.