Maybe? Depends on RNG and how good you are. I did my run in around 300 units. Granted I had a stronger team but I would suggest waiting for halls of healing then try it
g2099 is amazing for this challenge, used her for Howard, Gwenpool and Deadpool. i didn’t have to use a single revive for those fights because I could use her regen to maintain her health. for Warlock and Mysterio I used Cap IW max sig