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The Final Boss of Every Present and Future Variant Ever (for about 2 days)

Yep. I did this again. The Final Boss of every variant (present and future) at the time of writing this. First 6 are set as they are, rest are speculation.
Ultron’s Assault: AOU Ultron - EMP Modification, Force of Will, Fisticuffs, and Limber. I actually have somewhat first-hand experience with this fight, as I talked an irl friend through his completion run. Not too terribly bad if you have a Gulk or Medusa, ideally someone who can either stop him from throwing specials or just kinda ignores the EMP Mod.
Mystery in the Microrealms: Yellowjacket - Encroaching Stun, Enhanced Special 1, Debilitate, Critical, Enhanced Critical Buffs, and Limber. Once again, not too terribly bad with ideal counters. Venom works well, Hyperion is good, and plenty of others get it done as well. Just watch that encroaching stun timer.
Polar Opposites: Kang - Selective Timestream, Picture of Health, Enhanced Special 1, and Enhanced Special 2. Sentinel works a treat for this fight. IMIW, as well as anyone that can apply shock and/or incinerate to negate selective timestream works.
Waning Moon: Moon Knight - Will of Khonshu, Echo Barrier, Enhanced Special 2, Bleed Vulnerability, and Force of Will. Any one star can do this fight, but it’s loads better with either Black Panther or Wolverine as they make the indestructible charges go away faster.
Blood and Venom: Venom - Enhanced Special 2, Anamnesis, Energize 1, Buff Duration, Mystic Ward, and Outlast. Doom. Voodoo. Magik. Easy game, easy life.
Contamination: Joe Fixit - Madness, Tyrant, Monster, Special 1 Bias, Superior Specials - 2, Strike Back, and Heavy-Hitter. Venom heavy spam, win game.
Arachnid Action: Miles Morales - Would imagine they throw in Enhanced Abilities and the combo of Spry and Gassed. Hard to tell what they’re doing with it as Miles is currently in the process of getting a buff
Deadpoolooza: Venompool - Um. How do you make a Venompool fight hard aside from ridiculous nodes?
Kamala’s First Day: Captain Marvel Classic - Again, how do you make this hard aside from utter ridiculous nodes?
M.O.D.O.K., Mo' Problems: Spider-Witch - Now, I wouldn’t see this being on the level of the Act 7 Spider-Witch, but a toned down version could be quite possible
Cosmic Civil War: This one has two. Depends on the side you chose in the theme of the event. (think Baron’s War but it determines your event quest) Iron Faction had a Falcon boss, which I could see being a decent challenge (maybe Lock-On is always active as a node) Cap’s Faction had BPCW. Probably one of those gain Armor nodes, possibly armor break immune.
Cosmic Civil War: Endgame: Captain America (WWII) - Again, how do you make this hard aside from utter ridiculous nodes? Add Enhanced Bleed, Caltrops, maybe Gassed?
X-Men: Terrigenocide: Beast - I’m fairly sure by the time this hits Beast will have buffed (much to the excitement of @DrZola ) but right now, can’t see a real way to make this hard.
Titanomachy: Loki - I can see this being a decent challenge depending on the nodes and overall variant theme
Terrigenocide: Part 2: Karnak - Is enhanced true strike a thing?
Terrigenocide: Part 3: Dark Phoenix - Don’t actually know her abilities but knowing Phoenix it can’t be that bad, right? Right?
Pandemonium Rising: Ghost Rider - Probably give him the Blade synergy benefits via nodes
Sorcerer’s Conclave: Mordo - Oh joy. Increased Power Gain, Energize, Power Reserve. I can see it oh so clearly.
Gwenpool: Agent of C.A.B.L.E.: Cable - Increased Power Gain, Enhanced Regen, Vigorous Assault, maybe some other things. Not as bad as Mordo!
Dawn of Darkness: Dormammu - Stuff to do with power, I guess.
X-Enforcers: Archangel - Enhanced Bleed & Poison. Enhanced Abilities.
King Groot’s Loot: King Groot - Probably just a very tanky King Groot.
Guardians of the Galaxy Vol. Zero: Thanos - There’s actually a lot I think the devs could do with this one. Maybe give him the stones?
Secret Empire Forever: Punisher 2099 - What’s that node that charges his battery faster? Probably some power lock things as well
Battlerealm: Homecoming: Vulture - Again, he’ll probably be buffed by now but
Sinister Foes of Spider-Man: Doctor Octopus - His research categories will likely go up faster, probably the node that heal blocks and power locks you at the start
Have You Seen This Dog?: Kingpin - Fight or Flight! Fight or Flight!
Blades: Mephisto - Picture of Health, Enhanced Regen, something to do with incinerates
Gods of the Arena: Thor Ragnarok - Combo Up-3, Increased Power Gain, Power Start 2.
Hotel M.O.D.O.K.: M.O.D.O.K. - Explosive Personality. Do it. I dare you.
The Age of the Sentry: Void - Long Distance Relationship, Footloose, Spry. ALL THE DEBUFFS FOR YOU
Rise of the Black Panther: Killmonger - There’s a lot to work with here. Armor Break immune isn’t a stretch.
X-Men: Savage Future: Sabretooth - Picture of Health, enhanced healing, adaptive for good measure
Infinity Chaos: Nameless Guillotine - Aspect of War, just like the original Uncollected Version. Well of Souls is a no brainer here as well.
Infinity Nightmare: Thanos - This is the special Infinity Gauntlet Thanos. I feel like adding additional node would be overkill.
Masacre And The Mercs For Money: Goldpool - Buffed up regen and prowess.
Return to the Micro-Realm: Ghost - Immune to Armor Break, enhanced cruelty
Enter the Cabal: Red Skull - More armor ups! Enhanced Power Drain! (that’s a thing, right?)
X-Men: Class Omega: Omega Red - Death Spores apply faster and fall off slower
Blood and Venom: Symbiomancer: Symbiote Supreme - Shatter, Prey on the Weak, faster power gain
Brawl in the Battlerealm: The Champion - Better furies, unstoppable, and regen
Night Riders: Darkhawk - Raptor Upgrades, could see special 2 bias as well
This Man… This Monster!: Diablo- Limber, Buffet, Aspect of Evolution.
X-Men: Xenoclast: Mister Sinister - Genetic Perfection, Bleed Vulnerability, the parry causes you to degen node
Battlerealm: Under Siege: Captain Marvel (Movie) - Binary Might, Energy Sensitive, Redoubled Determination, one of the special biases
The Living Death Who Walks!: Annihilus - Enhanced Armor Break, Freezer Burn, All or Nothing
Avengers Forever: Nameless Thanos - Once again, fancy Thanos that doesn’t need additional nodes
Imperius Rex!: Namor - enhanced bleed & regen, he builds his charges faster
Phantasmagoria: Mysterio - that set of nodes they always give mysterio
X-Machina: Warlock - Crumbling Armor, charges build faster
Amazing Fantasy: Claire Voyant - Shatter, enhanced bleed and poison, special 2 bis, bane of damballah
Guillotine: Future Prometheus: Mephisto - Once again, enhanced regen and some incinerate thing
When Titans Clash!: Doctor Doom - Shatter, Special 2 Bias, Power Drain/Burn/Lock 90% less effective
The Trial of Reed Richards: Silver Surfer - Enhanced Armor Break, Spectre, whenever he gains a buff he gains another one
Squirrels vs. Skrulls: Nova - Parry, Energize - 1, Special 2 Bias, Aggressive
X-Communication: Mojo - Icarus, Power Bond, Recovery, Aspect of Nightmares
Of Rocks and Rodents: Terrax - Powerful from Afar, Limber, Galactic Intervention - 1, Selective Timestream
From Beyond: Storm Pyramid X - Unblockable Specials, Aspect of War, energize 1, special 2 bias
Black Widow: Red by Dawn: Red Guardian - Unblockable specials, Debilitate, heal block
武者修行 - Samurai's Journey: Tigra - Special 2 Bias, Caltrops, Aggressive
Missing Links: Guardian - Advanced Force Field, Heavy-Handed, Insecurity
Annunciation of Ruin: Air-Walker - Increased Power Gain, Crumbling Armor, better armor breaks
Rise of X: Apocalypse - All champs are counted as mutant for his abilities, redoubled determination, enhanced bleed & poison
Recursion: Cosmic Ghost Rider - Increased Power Gain, Power Start 2, Special 2 Bias, Aggressive
The Immortal Hulk: Immortal Abomination - Enhanced Poison, Nano Plague, Acidic Erosion, Redoubled Determination
Spider-Ham: Framed by Fame: Spider-Ham - Dizzy, Feat of Indestructible - 1, Failure to Launch - 3
X-Men: Prodigal Son: Stryfe - Now You See Me, Power Thief - Miss
Mixed Emotions: Psycho Man - Enhanced Abilities, Crippling Failure, Heal or Hide
Sins of the Father: Mangog - Aggressive, Heavy-Hitter, Aspect of Genesis, Backboard Brawler, Power Start 1
Ultron’s Assault: AOU Ultron - EMP Modification, Force of Will, Fisticuffs, and Limber. I actually have somewhat first-hand experience with this fight, as I talked an irl friend through his completion run. Not too terribly bad if you have a Gulk or Medusa, ideally someone who can either stop him from throwing specials or just kinda ignores the EMP Mod.
Mystery in the Microrealms: Yellowjacket - Encroaching Stun, Enhanced Special 1, Debilitate, Critical, Enhanced Critical Buffs, and Limber. Once again, not too terribly bad with ideal counters. Venom works well, Hyperion is good, and plenty of others get it done as well. Just watch that encroaching stun timer.
Polar Opposites: Kang - Selective Timestream, Picture of Health, Enhanced Special 1, and Enhanced Special 2. Sentinel works a treat for this fight. IMIW, as well as anyone that can apply shock and/or incinerate to negate selective timestream works.
Waning Moon: Moon Knight - Will of Khonshu, Echo Barrier, Enhanced Special 2, Bleed Vulnerability, and Force of Will. Any one star can do this fight, but it’s loads better with either Black Panther or Wolverine as they make the indestructible charges go away faster.
Blood and Venom: Venom - Enhanced Special 2, Anamnesis, Energize 1, Buff Duration, Mystic Ward, and Outlast. Doom. Voodoo. Magik. Easy game, easy life.
Contamination: Joe Fixit - Madness, Tyrant, Monster, Special 1 Bias, Superior Specials - 2, Strike Back, and Heavy-Hitter. Venom heavy spam, win game.
Arachnid Action: Miles Morales - Would imagine they throw in Enhanced Abilities and the combo of Spry and Gassed. Hard to tell what they’re doing with it as Miles is currently in the process of getting a buff
Deadpoolooza: Venompool - Um. How do you make a Venompool fight hard aside from ridiculous nodes?
Kamala’s First Day: Captain Marvel Classic - Again, how do you make this hard aside from utter ridiculous nodes?
M.O.D.O.K., Mo' Problems: Spider-Witch - Now, I wouldn’t see this being on the level of the Act 7 Spider-Witch, but a toned down version could be quite possible
Cosmic Civil War: This one has two. Depends on the side you chose in the theme of the event. (think Baron’s War but it determines your event quest) Iron Faction had a Falcon boss, which I could see being a decent challenge (maybe Lock-On is always active as a node) Cap’s Faction had BPCW. Probably one of those gain Armor nodes, possibly armor break immune.
Cosmic Civil War: Endgame: Captain America (WWII) - Again, how do you make this hard aside from utter ridiculous nodes? Add Enhanced Bleed, Caltrops, maybe Gassed?
X-Men: Terrigenocide: Beast - I’m fairly sure by the time this hits Beast will have buffed (much to the excitement of @DrZola ) but right now, can’t see a real way to make this hard.
Titanomachy: Loki - I can see this being a decent challenge depending on the nodes and overall variant theme
Terrigenocide: Part 2: Karnak - Is enhanced true strike a thing?
Terrigenocide: Part 3: Dark Phoenix - Don’t actually know her abilities but knowing Phoenix it can’t be that bad, right? Right?
Pandemonium Rising: Ghost Rider - Probably give him the Blade synergy benefits via nodes
Sorcerer’s Conclave: Mordo - Oh joy. Increased Power Gain, Energize, Power Reserve. I can see it oh so clearly.
Gwenpool: Agent of C.A.B.L.E.: Cable - Increased Power Gain, Enhanced Regen, Vigorous Assault, maybe some other things. Not as bad as Mordo!
Dawn of Darkness: Dormammu - Stuff to do with power, I guess.
X-Enforcers: Archangel - Enhanced Bleed & Poison. Enhanced Abilities.
King Groot’s Loot: King Groot - Probably just a very tanky King Groot.
Guardians of the Galaxy Vol. Zero: Thanos - There’s actually a lot I think the devs could do with this one. Maybe give him the stones?
Secret Empire Forever: Punisher 2099 - What’s that node that charges his battery faster? Probably some power lock things as well
Battlerealm: Homecoming: Vulture - Again, he’ll probably be buffed by now but
Sinister Foes of Spider-Man: Doctor Octopus - His research categories will likely go up faster, probably the node that heal blocks and power locks you at the start
Have You Seen This Dog?: Kingpin - Fight or Flight! Fight or Flight!
Blades: Mephisto - Picture of Health, Enhanced Regen, something to do with incinerates
Gods of the Arena: Thor Ragnarok - Combo Up-3, Increased Power Gain, Power Start 2.
Hotel M.O.D.O.K.: M.O.D.O.K. - Explosive Personality. Do it. I dare you.
The Age of the Sentry: Void - Long Distance Relationship, Footloose, Spry. ALL THE DEBUFFS FOR YOU
Rise of the Black Panther: Killmonger - There’s a lot to work with here. Armor Break immune isn’t a stretch.
X-Men: Savage Future: Sabretooth - Picture of Health, enhanced healing, adaptive for good measure
Infinity Chaos: Nameless Guillotine - Aspect of War, just like the original Uncollected Version. Well of Souls is a no brainer here as well.
Infinity Nightmare: Thanos - This is the special Infinity Gauntlet Thanos. I feel like adding additional node would be overkill.
Masacre And The Mercs For Money: Goldpool - Buffed up regen and prowess.
Return to the Micro-Realm: Ghost - Immune to Armor Break, enhanced cruelty
Enter the Cabal: Red Skull - More armor ups! Enhanced Power Drain! (that’s a thing, right?)
X-Men: Class Omega: Omega Red - Death Spores apply faster and fall off slower
Blood and Venom: Symbiomancer: Symbiote Supreme - Shatter, Prey on the Weak, faster power gain
Brawl in the Battlerealm: The Champion - Better furies, unstoppable, and regen
Night Riders: Darkhawk - Raptor Upgrades, could see special 2 bias as well
This Man… This Monster!: Diablo- Limber, Buffet, Aspect of Evolution.
X-Men: Xenoclast: Mister Sinister - Genetic Perfection, Bleed Vulnerability, the parry causes you to degen node
Battlerealm: Under Siege: Captain Marvel (Movie) - Binary Might, Energy Sensitive, Redoubled Determination, one of the special biases
The Living Death Who Walks!: Annihilus - Enhanced Armor Break, Freezer Burn, All or Nothing
Avengers Forever: Nameless Thanos - Once again, fancy Thanos that doesn’t need additional nodes
Imperius Rex!: Namor - enhanced bleed & regen, he builds his charges faster
Phantasmagoria: Mysterio - that set of nodes they always give mysterio
X-Machina: Warlock - Crumbling Armor, charges build faster
Amazing Fantasy: Claire Voyant - Shatter, enhanced bleed and poison, special 2 bis, bane of damballah
Guillotine: Future Prometheus: Mephisto - Once again, enhanced regen and some incinerate thing
When Titans Clash!: Doctor Doom - Shatter, Special 2 Bias, Power Drain/Burn/Lock 90% less effective
The Trial of Reed Richards: Silver Surfer - Enhanced Armor Break, Spectre, whenever he gains a buff he gains another one
Squirrels vs. Skrulls: Nova - Parry, Energize - 1, Special 2 Bias, Aggressive
X-Communication: Mojo - Icarus, Power Bond, Recovery, Aspect of Nightmares
Of Rocks and Rodents: Terrax - Powerful from Afar, Limber, Galactic Intervention - 1, Selective Timestream
From Beyond: Storm Pyramid X - Unblockable Specials, Aspect of War, energize 1, special 2 bias
Black Widow: Red by Dawn: Red Guardian - Unblockable specials, Debilitate, heal block
武者修行 - Samurai's Journey: Tigra - Special 2 Bias, Caltrops, Aggressive
Missing Links: Guardian - Advanced Force Field, Heavy-Handed, Insecurity
Annunciation of Ruin: Air-Walker - Increased Power Gain, Crumbling Armor, better armor breaks
Rise of X: Apocalypse - All champs are counted as mutant for his abilities, redoubled determination, enhanced bleed & poison
Recursion: Cosmic Ghost Rider - Increased Power Gain, Power Start 2, Special 2 Bias, Aggressive
The Immortal Hulk: Immortal Abomination - Enhanced Poison, Nano Plague, Acidic Erosion, Redoubled Determination
Spider-Ham: Framed by Fame: Spider-Ham - Dizzy, Feat of Indestructible - 1, Failure to Launch - 3
X-Men: Prodigal Son: Stryfe - Now You See Me, Power Thief - Miss
Mixed Emotions: Psycho Man - Enhanced Abilities, Crippling Failure, Heal or Hide
Sins of the Father: Mangog - Aggressive, Heavy-Hitter, Aspect of Genesis, Backboard Brawler, Power Start 1
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