Epic SQ Mephisto nodes?

I can also recommend Void, but Cosmic Ghost Rider also worked surprisingly well for me. You have to wait out the initial soul imprisonment but after that you can play him fairly decently. You might have to change up the rotation somewhat so that you can maximize the power gain buff so that it allows you to reach 2 bars of power before Mephisto throws a special, but all in all it worked much better than I anticipated.

Hammerbro_64

Pro tip just do epic with general counters (void, HT with prefight) and if worst comes to worst you could probably nuke him down with whoever. Then you know mostly what nodes the higher difficulty has and you can adjust if need be.

Morpheus_123

Blade with danger sense activated works a treat.

Gercas

HT with pre fight against Mephisto is a cheat code

Negative_100

@odishika123
Thank you Spidey
Hmm I'll use Apocalypse

I actually used him too

zuffy

If you have torch, it’s super easy.

psp742

Human Torch can easily beat Mephisto

Tendersquad

Just Quake it

Colinwhitworth69

Havok is also fun.

The_beast123

Just a note guys. Don't use Torch without pre-fight, a blunder I did out of hastiness. There is no way we can afford to win the fight, unless he throws his specials often.

With pre-fight, it's a joke.

Menkent

No one uses void anymore?

GroundedWisdom

No one uses void anymore?

Um...yes?

Masterpuff

@odishika123
Thank you Spidey
Hmm I'll use Apocalypse
Apocalypse will not work well, too much power gain

I obliterated him with my apoc.

odishika123

@odishika123
Thank you Spidey
Hmm I'll use Apocalypse
Apocalypse will not work well, too much power gain
I obliterated him with my apoc.

Same here

Djin

No one uses void anymore?

I use him all the time. He still destroys anything and everything that is not debuff immune.