After reaching Isophene, Kabam unlocked more milestones above the original highest milestone in the realm event. Of particular interest were milestones 38 and 43. Milestone 38 at 4,640,000,000 points contains an R2->R3 rank up crystal, and Milestone 43 at 5,040,000,000 points contains a trophy champ selector with 7* Vision, Kang, and Thanos. How likely are we to reach both milestones?
Well, as I write this we just surpassed milestone 38, so that one is a done deal. Are we on track to reach milestone 43?

At the moment, yep. Orange line is the pace car to reach milestone 43, and the blue line is our current progress since day four. If we look at our scoring rate verses the necessary rate to reach milestone 43, we get:

It is not as much of an absolute certainty as it was for Isophene or milestone 38, but we have consistently been above the necessary rate to reach milestone 43. Yes, it is possible our scoring rates will drop over the last three days of the event, but remember that the necessary rate also drops whenever we score more than the necessary rate. The necessary rate required as I write this is about 4.6 million points per hour. We've never been below that rate, and the current rate is 7.5 million per hour. The overnight rate has been bottoming out around 5 million points per hour, and the average overall rate has been fluctuating between 6 million/hour and 7 million/hour for the past five days or so.
I expect a burst of points to come in before the end. It might not be a huge one, but it doesn't have to be. My current projected final score is about 5.15 billion, plus or minus. We just need to reach 5.04 billion. To see the big picture scoring rate trend here's how many points we've been scoring per day.

Did scoring drop off after the first couple of days? By a ton. Did it continue to drop? Well, it looks more like it leveled off for the most part over the last five or six days. If the daily scoring continues to look more or less like that, we'll make it to milestone 43.