I personally think Gambler's fate is the worst buff in the game. Other buffs like Starburst, Spiked Armor, Spite, are all horrible but you can prepare for them and plan your fights with some sort of strategy and still implement skill... Gambler's fate though...

.... Oh look I have bleed, the poison then bleed, then degen, then power lock.... Oh look the AI has Regen, Power Gain, Power Flood, Bleed, Degen, Unstoppable.... It's just one big cluster F of luck and relying on RNG takes out all the skill.
Would be nice if it just didn't show up anymore.... ever... Like The Maze...
What do you think is the worst buff?