New mastery suggestions
Power Fatigue: X% chance that a critical hit does not give the opponent power.
Soul Lock: whenever your opponent is below X% health. Theres a Y% chance that your opponent gets power locked for (number) seconds.
Endurance: your champions gain an additional X% attack while your champions are under a debuff. This effect gets reduced while your champions have a buff active and increases on the number of debuffs your champions have.
Enhanced Poison: poison effects that your champions inflict are X% more effective and last Y% longer.
Very Deep Wounds: bleed effects your champions inflict reduce your opponent's ability accuracy by X%. This is affected by class relationships.