The Wolverine node in RoL can be fun to try and bring champs to either “Heal Block” him, or better yet “Reverse Heal” him. Or “Steal” the Regen (can Loki do that ?)
Old timey ones like OG Guillotine (updates she received over the years, plus additions to her synergies, makes this even easier to do. But was an option even how she originally was too)
If you have deathless champs, then you'll be fine going into RoL with anyone(as you have to do some content to get the 6* pieces, and that content was harder than RoL). Just being a heal block champ for Wolvie. For LoL, I'd suggest waiting and clearing other content first. Rewards aren't good for effort (time or resources).
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Old timey ones like OG Guillotine (updates she received over the years, plus additions to her synergies, makes this even easier to do. But was an option even how she originally was too)
Or several others added to game since then.