Quake might have gotten my vote except for the simple fact that she is not available as a 6*.
6*R3 Ghost > 5*R5 Quake. My opinion might change should Kabam ever release a 6* Quake.
It have to change, with all the difficult counters they add + with tons of R3 defenders and high health pool on different content. She's seriously getting VERY boring to use, fights take so long, but she still the one that saved me the most units ever. She still the best imo.
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6*R3 Ghost > 5*R5 Quake. My opinion might change should Kabam ever release a 6* Quake.