Mysterio... not because he is difficult. SP1 and SP2, easy enough to evade, but he is stupidly trigger happy with that heavy attack. I find it annoying that he catches me napping.
Venom with Special 2 Bias is one of my least favorite fights. Generally, my least favorite defenders are Bishop, P2099, and Punisher. That block damage blows
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On high end content, his degen is annoying and very strong.
Every. Single. Time.
Also don’t know how to deal with the one in V5
Generally, my least favorite defenders are Bishop, P2099, and Punisher. That block damage blows
My most hated opponent (and champion in general design-wise) is Doom.