If you can, 4* Spider-Man or Gwenpool (or possibly Medusa but I find she's only affective with the right synergies) should be your focus. These are god-tier champs.
Agreed Medusa to 5/50 (only if you have champs for her synergy. This is based off single player quest in my experience. Someone else may have more knowledge of her.) If not then definitely Spidey Stark first. (Like Medusa he's an end game champ, without the baggage of needing specific Champions to boost him. Unlike Medusa) If you still don't have the synergy champs for medusa. Then go Gwenpool because she's a big damage dealer + bleed and stun. As well as minimal power control. Even if she's not dupped. 3 really solid champs which makes it a tough call. I suppose it will come down to your personal game play style (Parry, evade, intercept.. ect.) That's my 2 cents.lol best if luck on your journey!
I would rank up Medusa. However, Stark Enhanced Spider-Man and Gwenpool are great champions as well! Venom would be great since you don't have a lot of high leveled champions!
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