You could wait a very long time for Symbiote Supreme. I would not do that since you have two very nice mystic champs on your roster already in Dormammu and Mephisto. Besides, you could get lucky and get another mystic awakening gem as you are lucky to pull Symbiote Sumpreme. Either scenario takes time. In the mean time, if you need to progress in your game content and requires a strong mystic champ, these two can help. Dormammu is a nice option because he has immunity to poison and bleed and is useful to have in AQ and in quests to face nodes that have those effects. He is much better awakened and need that more than Mephisto. Do you have a 5* poison or bleed immune champ on your roster already? Would be better to advise you if you can provide info on where you are in your game with respect to story quest, monthly quests, AQ completion or what is it you are trying to do in your game.
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