I don't think you could go wrong with any of those, but it depends on what you're trying to accomplish. I assume Act 5? Personal preference would be Domino. Second choice would be Luke Cage for bleed immunity. I don't particularly care for Killmonger and haven't used Symbiote Supreme.
Domino is the best damage dealer for content here. Doesnt need her sig ability. Killmonger is good but not as useful and damage isnt great. Run a red hulk with domino and you will kill kost content in fewer than 5 heavy attacks.
all of the options seem perfectly fine. my preference is luke cage, too bad he's not awakened. i also like killmonger, he's pretty good against evade champions and can take sp3. domino is just amazing. I don't a symbiote supreme but he looks great, however i think he's much better awakened
so... I'd say go with the one you feel more comfortable playing with
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so... I'd say go with the one you feel more comfortable playing with