Generic ISO. Keep or Sell?

I just completed act 3 and I've been pulling some pretty decent champions lately. I'm running low on gold (100k). I do not have a lot of class ISO, so the only mean of upgrading my champions I have is generic ISO. Some experienced players have told me that I should sell all generic ISO. So should I sell it and wait for my class ISO to increase or should I use up as much as I can? Thanks in advance
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