Domino. Blade is still great but, in my opinion, he relies way too much on danger sense and bleeds to be effective so in cases where the opponent is immune or a hero he doesn’t hit extraordinarily hard. Domino on the other hand crits like a maniac so her damage is great regardless. One caveat, if you’re a player who isn’t confident in their ability to not get hit then blade might be better just for his regen but if you don’t use it often I’d say domino all day.
I find Domino more useful, because she rocks even without synergies, unlike Blade. Additionally, you can expect at least 2 new heroes added this year (F4) and supposedly another 2 next month (Phoenix is ingame character already and I guess Professor X and Mystique are likely to be released.), so I don't theink Blade is that good anymore
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I like playing Blade more than Domino. blade has regen and his synergy with ghost rider goes a long way in questing.
If you like parry heavy playstyle, go for Domino.