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Is ACT 5.3 and 5.4 first run worth attempting with my roster?

All unduped unless stated
4/55 Cap Iw
4/55 Gladiator hulk
3/45 Archangel
5/50 Duped scarlet witch, duper hyperion, duped archangel, gwenpool
4/55 Cap Iw
4/55 Gladiator hulk
3/45 Archangel
5/50 Duped scarlet witch, duper hyperion, duped archangel, gwenpool
0
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Google “easiest path for act 5.3” and you may find a lot of good resources in Reddit. Good luck!