Using guillotine against wolverine , you need to be very lucky.
If you have skill, duped SL, Archangel, Vision ,Yondu, or even Loki, Rogue and Dr.voodoo are possible options.
You need to unleash her 2nd special in the first 20 seconds of the fight. ROL Wolverine is the original version of when he came out. Meaning that he'll heal with every critical hit and gives or receives. So having Precision maxed out will be helpful, Mystic Dispersion is helpful even at 1 point. Took down ROL Wolverine with 78 hits.
No that's the current Wolverine that we all have. The ROL Wolverine never changed unless it was some time this year. That's why some people say you can beat him with Crossbones cause he doesn't have critical attacks.
The easiest way is to use Guillotine. If you can catch him with two or three stacks of regen before hitting him in that first 20 seconds of the match then he quickly loses health from it. Typically after that some people will quit and restart to ensure that Guillotine has more souls available to do the same thing again. The most important thing when using her is ensuring she has at least two souls and that Wolverine has multiple stacks of regen when you drop that s2 on him.
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If you have skill, duped SL, Archangel, Vision ,Yondu, or even Loki, Rogue and Dr.voodoo are possible options.
Otherwise surely crossbones would be the best option?
His bleeds are critical
His regen is all attacks