Omega Red is better the more of these he has: high signature, suicides, Sabretooth synergy. However, in my opinion, if you have none of those 3, I would not R4 him. He still is a very good champion: poison immune, almost bleed immune and can deal very well with Poison, Bleed, Biohazard and Caltrops nodes.
About Dr. Voodoo, I would not R4 him unduped. But I am sure others will disagree.
Omega red is a great champ to tackle 6.1.5 crossbones, so he's the best champ to take up in the long run, undoubtedly one of the best champs in the game
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About Dr. Voodoo, I would not R4 him unduped. But I am sure others will disagree.