5.4.5 Mephisto

Is a 4* 3/30 Human Torch enough to beat the 5.4.5 Mephisto boss, or should I rank him up? Does he need sig? I have an awakening gem I can use but only a few sig stones, so I wouldn't be able to get him to a high sig.
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@Lvernon15 What kind of team would work well against Ultron? Not sure what can actually kill him.
How. Do. I. Get. To. Full. Power.
EDIT: Wait. Does Karnak synergy help here?