Rank Up Advice (2)

OmegaRed was my first 5/65 champ in game. I was planning on maxing out Colossus next but also have Domino as of yesterday. Who will help more as I get into Act 6?

Also not sure what to do with a variant skill gem rank 3 > 4. I have Stealth spidey sitting at R3 (unawakened) and Blade (now awakened) at 1/25.

Grateful for any advice. Thx.

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