What is the best mastery setup to use around Omega Red?

I want to maximize the potential of Omega Red, and I know that suicide masteries, willpower, and coagulate are all great to have for him and help him a lot, but they cost a ton of units. My other questing champions are Medusa (poison immune), Colossus (bleed immune), Blade, Cap IW, and Emma Frost who I use sometimes (Bleed and Poison Immune). Is it worth getting that entire mastery setup just for Omega Red? Will it benefit my other champions as well?
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Maybe look at running suicides when you get more suicide friendly champs?